The Area 51 crew travel to Chicago, Illinois to tattoo at C2E2, one of the largest pop culture conventions in the country. But before heading out, Chris 51 tattoos an octopus wrapped around his client's shoulders. Caroline must stay behind to watch the shop, while Heather works on a client who wants a "birthed" unicorn in a his hairy armpit. Back in Chi-town, Josh tattoos a realistic Donatello from Teenage Mutant Ninja Turtles 1990 film and Jeff inks a heavy metal-inspired R2D2/C-3PO tattoo, while Chris Jones creates a RoboCop portrait.