Mr. Neighbor invites people to his "31st annual 5th birthday party" like his roommate Buddy, the librarian Ms. Lady, Chef Bread, the mailman Photo Joe, Donna the Mystic, King Id, Queen Super Ego, Spaghetti Face, Officer Policecop, Friendly Ghost, Grandma Wrinkles, a Cheerleader, Duff and Daisy, Dying Wizard, Ice Cream Bruce, Scarf Monster, Devon, Carl, and Cat Bird. Due to traumatic events involving his mother walking out on his father and never returning, Mr. Neighbor begins to have a psychological breakdown.