Khalil Payne is a young man ridden with the guilt of his troubled past from his former life in Freeland City, where, as a super-enhanced killing machine known as Painkiller, he was both a member of Tobias Whale's gang and a weapon of Agent Odell and the shadowy ASA. After attempting to bury the darker, devastatingly lethal Painkiller part of his persona, Khalil has distanced himself away from everyone he knows and loves in a new city, Akashic Valley, in order to find peace... but peace never comes easy for men with pasts like Khalil Payne and Painkiller. As his violent, destructive history crashes his idyllic new beginning, Khalil is thrusted back into action with a new mission - bring justice where he once gave out punishment - but to do that, he will first have to deal with and harness his darker side, Painkiller.