During a dangerous operation, the Dresden commissioner Karin Gorniak is seriously injured. The wanted murderer escapes and Karin's new colleague Leonie Winkler has to take on the case. Karin Gorniak is discharged from the hospital. She was the only one who saw the perpetrator and could identify him. After first being transferred to the evidence room, she helps her new colleague to identify suspects. Karin Gorniak agrees to a comparison. The group of suspects can be limited to two menbe narrowed down: the surgeon Dr. Christian Mertens and the nurse Bernd Haimann. However, just before the investigators can question the orderly, he disappears. Karin is now certain that Dr. Mertens is the perpetrator, but his wife gives the doctor a secure alibi.
Karin doubts her own judgment and loses the support of her boss, Schnabel. Leonie Winkler begins to fight for her colleague. Together, the investigators succeed in getting ever closer to the perpetrator.