MSC Flaminia is transporting thousands of containers across the Atlantic, en route to Belgium, when a massive fireball erupts from the cargo hold. With many of the containers full of dangerous goods, the officers, crew, and passengers must abandon ship before another explosion occurs. When investigators struggle to determine the cause of the disaster, they bring in an expert chemist; she discovers traces of a chemical cocktail that turned the ship into a pressure cooker ready to go off. It's a danger that threatens shipping around the world.