In the first featured story, Callahan travels to the picturesque town of Cape Coral, Florida to learn more about the disappearance of 29-year-old single mother, Lauren Dumolo, who was reported missing on June 19, 2020. In his quest to bring Lauren home, Callahan uncovers dark secrets and learns that certain people in Lauren's life might not have had her best interest at heart. Then, Callahan travels across the state to Ft. Lauderdale and immerses himself in the 2017 missing persons case of then 15-year-old Sophie Reeder, who snuck out from her father's home in the late evening hours on Friday, May 19.  When his investigation takes a turn into the shadowy world of the dark web, Callahan takes a deeper dive into the epidemic of human trafficking, and uncovers clues that Sophie might have fallen in the hands of those who perhaps groomed and targeted her.In both cases, few clues are left behind, leaving Callahan to conduct boots-on-the-ground investigations into these disappearances. Speaking with law enforcement and the victim's family to understand the circumstances surrounding the fateful day they were last seen, Callahan works to reveal any leads or information that have been unearthed since they've been gone and asks viewers to call if they have information on the cases.IN PURSUIT: THE MISSING also spotlights missing children cases from around the country, including: the July 10 disappearance of 10-year-old Breasia Terrell from Davenport, Iowa;  the August 4 disappearance of 12-year-old Jaylen Griffin from Buffalo, New York; the May, 2019 disappearance of then-16-year-old John Riser from Washtoukna, Washington; and the 2015 disappearance of then 5-year-old Ava Baldwin from San Antonio, Texas, which includes an age-progression photo provided by NCMEC to help guide the public on what she might look like now that she's 11.