Luke and Lizzy have been inseparable since childhood. Now all grown up and in their 30s, they have decided to have a baby - in a non-traditional way. Lizzy, who is gay, is really ready to become a mom and who better to be the dad than her best friend Luke. Then, just as Lizzy discovers she is actually pregnant, Luke surprises her with the news that he has fallen in love and married Prudence, a free-spirited, British beauty who was due to go back to England in a matter of days. Suddenly, a different kind of family is born and the three must learn how to make it work together.