Childhood friends Anton de Monteverde (JC DeVera) and Wacko Guerrero (Neil Coleta) vow to stay friends forever, even if fate splits them. True enough, when Wacko’s family migrates to Japan, the bond between them remains intact. After more than 15 years of separation, Anton, now a successful leadership speaker, is excited to be reunited with his childhood best friend. However instead of meeting Wacko at the airport, he meets beautiful but outlandish Winona Valencio (Roxanne Barcelo), who happens to be Wacko’s fiancée. Skeptical that Wacko would fall in love with a woman like Winona, Anton is forced to deal with her eccentricities and soon is shocked to find himself in his BFF’s shoes. Anton realizes that Winona is the woman destined to end his “auto-pilot” kind of life, boring nightlife gimmicks, and insignificant affairs. Winona is destined to become his greatest love.