The Cures race to the second MegaByogen, created by Shindoine to pollute a river, managing to purify it before Cure Fontaine receives power from the Water spirit. The final MegaByogen created by Daruizen is terrorizing a meadow of flowers. However, their encounter with it was unsuccessful as the MegaByogen's infection on the area was now too powerful for the Cures and overwhelms them. After the attack, Daruizen noticed that the MegaByogen created a dark seed that went somewhere. As they regroup, the trio was about to give up until the other earth elemental spirits rushed into the area where the MegaByogen is. The trio again transform and went back to fight against the more powerful MegaByogen. As all hope is about to be lost, Cure Grace encourages the Flower Spirit to not give up, which combines with the other spirit powers, causing the Miracle Healing Bottle to appear. The Cures perform Healing Oasis to defeat the MegaByogen and purify the Flower Spirit. However, the seed from the last MegaByogen goes unnoticed and infects a Nutria.