Manfred Bernardo, a powerful psychic on the run, decides to hide out in the small, sleepy town of Midnight, Texas. But when he's haunted by the ghost of a recently murdered Midnighter, Manfred discovers this sleepy community is a mysterious safe haven for outsiders with secrets - both supernatural and human - including Lemuel, an energy-leeching vampire; Olivia, a beautiful assassin; Fiji, a witch with a cranky cat; Creek, a spunky writer with big dreams; Bobo, a pawnshop owner with a hidden past; the Rev, who has an obsession for animals; and Joe, an angelic tattoo artist. In addition to the colorful residents, Manfred learns the town itself sits on a veil between the living and dead. He pledges to join the Midnighters in the fight to protect their home from suspicious cops and other outside forces.