Debbie wants her family's first Thanksgiving at their new home to be different from Thanksgivings past, so she convinces Marty to un-invite his parents and decides to invite Larry, Jackie, Reggie and Dick over for the holiday instead. Unfortunately, despite his promise to Debbie, Marty caves to parental pressure and confirms his mother and father will be on hand for Turkey Day. Meanwhile, after learning the meaning of the holiday, Dick secretly invites Jackie's estranged sisters, Venus and Serena, to make an appearance. Thanksgiving Day is anything but normal with the crazy alien neighbors, alien and human in-laws, and the Weavers all under one roof.